Frank J M van Kuppeveld Selected Research

Picornaviridae Infections

4/2024	Picornavirus security proteins promote the release of extracellular vesicle enclosed viruses via the modulation of host kinases.
3/2024	Assessment of Kinome-Wide Activity Remodeling upon Picornavirus Infection.
10/2014	Induction and suppression of innate antiviral responses by picornaviruses.
11/2012	MDA5 detects the double-stranded RNA replicative form in picornavirus-infected cells.
1/2010	Cross-talk between human dendritic cell subsets influences expression of RNA sensors and inhibits picornavirus infection.

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Frank J M van Kuppeveld Research Topics

Disease

56	Infections 03/2024 - 06/2007
11	Virus Diseases (Viral Diseases) 11/2023 - 12/2007
7	COVID-19 01/2023 - 01/2020
6	Enterovirus Infections 01/2020 - 05/2010
5	Picornaviridae Infections 04/2024 - 01/2010
3	Vesicular Stomatitis 12/2019 - 04/2005
2	Bites and Stings (Sting) 03/2024 - 11/2015
2	Common Cold 12/2023 - 11/2014
2	Persistent Infection 07/2022 - 11/2009
2	Influenza in Birds (Avian Flu) 01/2022 - 05/2015
2	Human Influenza (Influenza) 11/2021 - 10/2018
2	Neoplasms (Cancer) 12/2015 - 05/2015
2	Diarrhea 08/2015 - 07/2014
2	Porcine Reproductive and Respiratory Syndrome (PRRS) 01/2014 - 01/2010
2	Melanoma (Melanoma, Malignant) 05/2010 - 03/2008
1	Coinfection 12/2021
1	Myocarditis (Carditis) 01/2019
1	Aseptic Meningitis 01/2019
1	Foot and Mouth Disease Hand (Hand, Foot, Mouth Disease) 01/2019
1	Conjunctivitis 01/2019
1	acute flaccid myelitis 01/2019
1	Respiratory Tract Infections (Respiratory Tract Infection) 12/2018
1	Necrosis 01/2018
1	Chronic Disease (Chronic Diseases) 01/2017
1	Inflammation (Inflammations) 02/2016
1	Latent Infection 02/2016

Drug/Important Bio-Agent (IBA)

23	Antiviral Agents (Antivirals)IBA 03/2024 - 06/2007
19	Proteins (Proteins, Gene)FDA Link 03/2024 - 04/2005
8	RNA (Ribonucleic Acid)IBA 01/2023 - 01/2010
7	Interferon Type IIBA 03/2024 - 12/2007
6	Peptide Hydrolases (Proteases)FDA Link 01/2022 - 03/2014
5	VaccinesIBA 01/2023 - 11/2002
5	Viral RNAIBA 07/2022 - 01/2010
5	EpitopesIBA 01/2021 - 01/2016
4	Phosphotransferases (Kinase)IBA 04/2024 - 01/2020
4	DNA (Deoxyribonucleic Acid)IBA 03/2024 - 10/2009
4	AntibodiesIBA 01/2021 - 08/2013
3	CytokinesIBA 03/2024 - 06/2007
3	Hemagglutinins (Hemagglutinin)IBA 09/2023 - 05/2015
3	InterferonsIBA 01/2023 - 03/2008
3	Monoclonal AntibodiesIBA 01/2023 - 01/2020
3	N-Acetylneuraminic Acid (Sialic Acid)IBA 10/2022 - 02/2016
3	LigandsIBA 12/2019 - 01/2014
2	ProteomeIBA 03/2024 - 01/2020
2	LipidsIBA 03/2024 - 11/2014
2	EnzymesIBA 03/2024 - 01/2018
2	Neuraminidase (Sialidase)IBA 09/2023 - 11/2021
2	Messenger RNA (mRNA)IBA 01/2023 - 01/2010
2	Sialic AcidsIBA 01/2023 - 10/2018
2	Peptides (Polypeptides)IBA 01/2023 - 01/2022
2	PolyproteinsIBA 01/2022 - 11/2017
2	TrypsinIBA 08/2015 - 07/2014
2	CaspasesIBA 03/2014 - 07/2009
2	Pattern Recognition ReceptorsIBA 01/2014 - 01/2010
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 05/2010 - 03/2008
2	Nuclear Pore Complex Proteins (Nucleoporins)IBA 04/2009 - 03/2006
1	Viral ProteinsIBA 04/2024
1	Phospholipids (Phosphatides)FDA LinkGeneric 03/2024
1	phosphatidylinositol 4-phosphateIBA 03/2024
1	Itraconazole (Sporanox)FDA LinkGeneric 03/2024
1	NucleotidesIBA 03/2024
1	Polysaccharides (Glycans)IBA 01/2023
1	Carisoprodol (Soma)FDA LinkGeneric 01/2023
1	GlycosphingolipidsIBA 01/2023
1	ensovibepIBA 12/2022
1	Heparitin Sulfate (Heparan Sulfate)IBA 10/2022
1	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)IBA 10/2022
1	SARS-CoV-2 spike proteinIBA 01/2022
1	Neutralizing AntibodiesIBA 01/2022
1	Peptide LibraryIBA 01/2022
1	sialic acid receptorIBA 01/2022
1	Interleukin-7 (Interleukin 7)IBA 01/2021
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2020
1	Protein Kinases (Protein Kinase)IBA 01/2020
1	Broadly Neutralizing AntibodiesIBA 01/2020
1	Double-Stranded RNA (RNA, Double Stranded)IBA 01/2019
1	Membrane LipidsIBA 01/2019
1	eIF-2 Kinase (eIF 2 Kinase)IBA 01/2019
1	Metalloproteases (Metalloproteinases)IBA 01/2019
1	AcidsIBA 12/2018
1	Interferon-betaIBA 01/2018
1	Carrier Proteins (Binding Protein)IBA 01/2018
1	UbiquitinIBA 01/2018
1	LuciferasesIBA 01/2018
1	Interferon alpha-beta Receptor (Receptor, Interferon alpha beta)IBA 01/2018
1	Uridylate-Specific EndoribonucleasesIBA 01/2017
1	Membrane Glycoproteins (Membrane Glycoprotein)IBA 01/2017
1	MicroRNAs (MicroRNA)IBA 02/2016
1	Epstein-Barr virus encoded RNA 1IBA 02/2016
1	Formaldehyde (Formol)FDA Link 01/2016
1	GTP-Binding Proteins (G-Protein)IBA 01/2016
1	DisulfidesIBA 01/2016
1	Gemcitabine FDA Link 12/2015
1	NucleosidesIBA 12/2015
1	Ribavirin (Virazole)FDA LinkGeneric 12/2015
1	FurinIBA 08/2015
1	OSW 1IBA 05/2015
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 11/2014

Therapy/Procedure

6	Therapeutics 12/2022 - 10/2013
1	Intranasal Administration 01/2022